منابع مشابه
Melanocyte regeneration in vitiligo requires WNT beneath their wings
Melanocytes in patients with vitiligo possess intrinsic abnormalities that contribute to its pathogenesis. Regazzetti et al. report that CXCL10 expression reflects subtle inflammation in normal-appearing skin but not in stable depigmented lesions, supporting the hypothesis that melanocytes themselves initiate autoimmune inflammation prior to clinically evident disease. In addition, they find th...
متن کاملInterleukin 1-α: A Modulator of Melanocyte Homeostasis in Vitiligo
Background: Vitiligo is a hypomelanotic autoimmune skin disorder arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes leading to selective destruction of melanocytes. High levels of Interleukin 1(IL1) have been reported in various autoimmune disorders including vitiligo. The aim of present study was to explore the effect of IL1-α...
متن کاملThe Effect of Otic Melanocyte Destruction on Auditory and Vestibular Function: a Study on Vitiligo Patients.
The hallmark of vitiligo is the disappearance of melanocytes from the skin. As a result, of melanocytes presence in the auditory and vestibular apparatus, the involvement of these systems in vitiligo which targets the melanocytes of the whole body is possible; suggesting that vitiligo is a systemic disease rather than a purely cutaneous problem. A total of 21 patients with vitiligo were enrolle...
متن کاملconsequence analysis of the leakage, ignition and explosion during high pressure sour gas injection process to the oil reservoir
there is no doubt that human being needs to become integrated with industry and industry needs to be progressed, daily. on the other hand, serious events in industrial units specially in oil industries has been shown that such damages and events are industry related ones. the consequence of such events and damages which resulted in chemical and poisoned explosions and loss of life and property ...
Immunohistochemical analysis of melanocyte content in different zones of vitiligo lesions using the Melan-A marker.
INTRODUCTION Occurence of vitiligo lesions is caused by the destruction of melanocytes in a ected skin and therefore by the re- duction of pigment melanin content. Questions remain about the presence of residual melanocytes in the depigmented skin and optimal methods of their identi cation. METHODS Skin biopsy samples from 16 patients with non-segmental vitiligo and from 10 healthy volunteers...
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ژورنال
عنوان ژورنال: Indian Journal of Dermatology
سال: 2009
ISSN: 0019-5154
DOI: 10.4103/0019-5154.57604